〈Original Papers〉Studies on Cosmetic Whitening Effect and Antibacterial Activities of Dry Persimmon Peel (Diospyros Kaki THUNB.)

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[SUMMARY] Persimmon peels (Diospyros Kaki THUNB.) are discarded during the production of dried fruit. The 2-methoxy-4-vinylphenol (8) which is component of persimmon peel had high antioxidant activity on the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging assay and SOD (superoxide dismutase) assay. And (8) had higher tyrosinase inhibiting activity than that of arbutin using both L-tyrosine and L-DOPA as substrates. In addition, tyrosinase inhibitting activity of synthesized 2-methoxy-4-vinylphenol glycoside (12a) was studied. (12a) had tyrosinase inhibiting activity, suggesting that (12a) has possibilities for ingredient of cosmetics that are possessed of whitening effect. Moreover, for the creation of high value added product, we composed glycoside of (8) and cell toxicity assay with homosapiens origin alveolus epithelium cell strain A549 was carried on toward for these two kinds of compounds. Under high density condition (100 μg/mL), both of the compounds were not found to present toxic liability. Furthermore, we discovered that extracted hexane of dried persimmon include antibacterial activity (B. subtilis NBRC 3972, S. aureus NBRC13276 and E. coli NBRC3972) and ascertained methyl tridecanoate, 9-methyl hexadecenoate, 9-methyl octadecenoate, methyl tetradecanoate as the main components. Consequently we examined these components as the factor of antiseptic effect.

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