書誌事項
- タイトル別名
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- Structural Determination of Novel Acylpolyamines from the Venom of Nephila clavipes, a Brazilian Joro spider
- ブラジルサン ジョロウグモ カラ タンリ サレタ シンキ アシルポリアミン ノ コウゾウ ケッテイ
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Acylpolyaminetoxins in spider venom are known to inhibit glutamatergic neuromuscular transmission of arthropods or glutamate receptor in the mammalian central nervous system. Therefore, these toxins seem to be valuable for elucidating the mechanism of glutamatergic neurotransmission in the brain. Recently, a fraction containing novel acylpolyamine with molecular weight of 787 was obtained from Nephila clavipes, a Brazilian Joro spider, by HPLC purification of the crude venom. Three kinds of structures composed of five amino acids and one polyamine were proposed to these compounds by means of MS/MS analysis of the fraction. In the proposed structures, the sequence of four residues at left side in each molecule is the same. However, they differ from each other in the composition or the sequence of two amino acid residues at right side. In the present study, the chemical syntheses of 1~3 and the comparison of synthetic compounds with natural products by means of MS-MS analysis were carried out to determine the structures of novel acylpolyamines.
本文データの一部はCiNiiから複製したものである。
Departmental Bulletin Paper
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収録刊行物
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- 近畿大学理工学部研究報告
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近畿大学理工学部研究報告 (41), 23-29, 2005-09-01
近畿大学理工学部
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詳細情報 詳細情報について
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- CRID
- 1050001202557032448
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- NII論文ID
- 110004615585
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- NII書誌ID
- AN00064168
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- ISSN
- 03864928
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- NDL書誌ID
- 7866596
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
- CiNii Articles
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