ヒストンデアセチラーゼの阻害と制がん効果

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  • ヒストンデアセチラーゼ ノ ソガイ ト セイガン コウカ
  • Histone Deacetylase Inhibition and Anticancer Effects

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Abstract

Histone deacetylase（ HDAC） is an enzyme that catalyzes the deacetylation of lysine residues in histone proteins.　The HDAC plays important roles in realizing the histone code, changing the epigenetic condition and regulating the gene expression in eukaryote. Inhibition of HDAC induces anticancer effects such as induction of apoptosis or cell-cycle arrest in many cancer cells. Therefore, HDAC inhibition is one of the new prospective treatments of cancer.　This review describes about the basic and clinical information of the HDAC inhibition focused on anticancer effects.

Journal

  • 秋田医学

    秋田医学 36 (1), 9-18, 2009-06-01

    秋田医学会

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