THE EFFECTS OF CIRCUMFERENTIAL WIRING ON CANCELLOUS BONE HEALING AFTER OSTEOTOMY IN OVARIECTOMIZED RATS

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Background : Osteoporotic fractures often occur at sites rich in cancellous bone. However, most animal models of fracture healing have been established using cortical bones, and the fracture healing process in cancellous bone has not been reported. Methods : Seven-month-old female Sprague-Dawley rats underwent ovariectomy (OVX). All rats underwent complete mid-sagittal osteotomy of the proximal tibia and were divided into a wiring group and a non-wiring group (n=14 each). Rats were sacrificed at 2 and 4 weeks after osteotomy, and bone histomorphometry was performed to evaluate the percentage of cancellous bone union and fibrous union. Results : The percentage of bone union was significantly higher in the wiring group than in the non-wiring group (p=0.004) at 2 weeks after osteotomy. There was also no significant difference between the wiring and non-wiring groups at 2 and 4 weeks after osteotomy regarding the percentage of fibrous union (2w : P=0.062, 4w : P=0.063). Conclusions : The circumferential wiring technique improved cancellous bone union at the osteotomy site of the proximal tibia in the ovariectomized rats. The wiring may improve cancellous bone union by improving contact at the bone-to-bone interface and reducing the interposition of fibrous tissue.

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  • 秋田医学

    秋田医学 38 (1), 21-26, 2011-06-01

    秋田医学会

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