The new era of autoimmune disease research

DOI IR (HANDLE) HANDLE PubMed Open Access

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Description

Recent genome-wide association studies have advanced our understanding of genetic factors that underlie systemic lupus erythematosus (SLE), a multifactorial autoimmune disease characterized by various clinical manifestations. SLE also has an environmental component, which can trigger or exacerbate the disease. Despite extensive efforts aimed at elucidating the cellular and biological abnormalities that arise in the immune system of patients with SLE, its pathology remains unclear. Lee and colleagues recently carried out gene expression profiling of patients with SLE followed by bioinformatics analysis and discovered the existence of abnormal regulatory networks and potential key molecules. The authors found that ATP synthesis and DNA repair pathways may be involved in the pathogenesis, providing a potential explanation for photosensitivity experienced by patients with SLE.

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Details 詳細情報について

  • CRID
    1050001202567117952
  • NII Article ID
    120006352194
  • DOI
    10.1186/ar3335
  • HANDLE
    2115/67290
  • ISSN
    14786354
  • PubMed
    21496236
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB
    • CiNii Articles
    • OpenAIRE

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