DNA replication-dependent binding of CTCF plays a critical role in adenovirus genome functions
説明
The expression of adenovirus late genes is shown to require viral DNA replication, but its mechanism remains elusive. Here we found that knockdown of CTCF suppresses viral DNA replication as well as late, but not early, gene expression. Chromatin immunoprecipitation assays indicated that CTCF binds to viral chromatin depending on viral DNA replication. These findings depict CTCF as a critical regulator for adenovirus genome functions in late phases of infection.
収録刊行物
-
- Scientific Reports
-
Scientific Reports 3 2187-, 2013-07
Nature Publishing Group
- Tweet
キーワード
- DNA Replication
- Gene Expression Regulation, Viral
- CCCTC-Binding Factor
- Chromatin Immunoprecipitation
- Transcription, Genetic
- Adenoviruses, Human
- Genome, Viral
- Article
- Chromatin
- Cell Line
- Repressor Proteins
- Viral Proteins
- [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
- Gene Knockdown Techniques
- Gene Order
- Humans
- Protein Binding
詳細情報 詳細情報について
-
- CRID
- 1050001202618546816
-
- ISSN
- 20452322
-
- HANDLE
- 2241/119599
-
- PubMed
- 23851926
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- Crossref
- KAKEN
- OpenAIRE
