Redox nanoparticle therapeutics to cancer — increase in therapeutic effect of doxorubicin suppressing its adverse effect

DOI IR IR (HANDLE) Web Site Web Site View 1 Remaining Hide 28 Citations 33 References Open Access

Bibliographic Information

Other Title
  • Redox nanoparticle therapeutics to cancer - increase in therapeutic effect of doxorubicin, suppressing its adverse effect

Search this article

Description

The ultimate goal of cancer chemotherapy is to achieve a cure without causing any adverse effects. We have developed a pH-sensitive redox nanoparticle (RNP(N)), which disintegrates under acidic conditions and exposes nitroxide radicals, leading to strongly scavenging reactive oxygen species (ROS). After intravenous administration of RNP(N) to tumor bearing mice, it effectively accumulated in tumors due to the leaky neovascular and immature lymphatic system and scavenged ROS, resulting in suppression of inflammation and activation of NF-кB, after disintegration of RNP(N) in the tumors. Pre-administration of RNP(N) prior to treatments with anticancer agents, doxorubicin, to tumor-bearing mice significantly suppressed the progression of tumor size, compared to low-molecular weight 4-hydroxy-TEMPO. Interestingly, the administration of RNP(N) suppressed adverse effects of doxorubicin to normal organs due to the scavenging ROS and suppression of inflammation, which was confirmed by reduction in lactate dehydrogenase and creatine phosphokinase activities in plasma. RNP(N) is thus anticipated as a novel and ideal adjuvant for cancer chemotherapy.

Journal

Citations (28)*help

See more

References(33)*help

See more

Related Projects

See more

Keywords

Report a problem

Back to top