N-ビオチニル-アミノ-β-シクロデキストリンの合成

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タイトル別名
  • Synthesis of N-Biotinyl-amino-β-cyclodextrin
  • N-ビオチニル-アミノ-β-シクロデキストリン ノ ゴウセイ

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The fact that α-biotin serves as a covalently bound "C0_2 carrier" is now unequivocally established. Though model studies such as carboxylation on ureid l'-N-of biotin has been reported, no appropriate biomimetic model study for a "C0_2 carrier" has been carried out. The titled compound(I)in which the biotinyl group is bound to an amide linkage withβ-cyclodextrin, was prepared with active-ester method in good yield. Compound I was purified by taking with preparative HPLC. The structure of (I) was providedby ^1H-nmr, ^<13>C-nmr, elemental analysis, HPLC and the paper choromatography of hydrolyzates, and decided to be 6-(mono-N-biotinyl)-amino-β-cyclodextrin.

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KJ00002409580

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