書誌事項
- タイトル別名
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- Sequence Variation of Epstein-Barr Virus (EBV)-encoded BARF1 Promoter in EBV-Associated Gastric Carcinoma
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抄録
Epstein-Barr virus (EBV)-encoded BARF1 is suspected to play an important role in development of EBV-associated gastric carcinoma (EBV-GC). The present study examined the sequence variation of BARF1-promoter region (‒488/+87) of EBV genomes detected in 22 Colombian and 17 Japanese EBV-GCs. In addition, the EBV genomes in throat washing samples from 11 Colombian and 9 Japanese healthy donors (controls) were examined. All the EBV strains isolated from healthy donors had the same BARF1-promoter-region sequence as the prototype strain B95-8. In contrast, the EBV-GCs showed the following 8 point mutations in comparison with the B95-8 strain: G→C at ‒367 in 2 Colombian EBV-GC cases; T→A at ‒356 in 1 Colombian EBV-GC case; C→G at +15 in 1 Colombian EBV-GC case; C→T at +24 in 5 Colombian EBVGC cases; T→G at +26 in 3 Colombian EBV-GC cases; T→C at +29 in 7 and 2 Colombian and Japanese EBV-GC cases, respectively; T→A at +44 in 5 Colombian EBV-GC cases; and G→A at +46 in 1 Japanese EBV-GC case. The observed casecontrol difference at position +29 was statistically significant (p=0.022, Fisher’s exact test). Although the frequency of this point mutation in Colombian EBV-GCs was higher than that in Japanese EBV-GCs, the difference was not statistically significant (p=0.251). In summary, the present study, examining the BARF1-promoter region of EBV genomes detected in 39 EBV-GCs and throat washing specimens from 20 healthy donors, found a statistically significant increase of the point mutation of T→C at position +29 in EBV-GC. Further studies seem warranted to clarify the etiological significance of this finding.
収録刊行物
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- 鹿児島大学医学雑誌
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鹿児島大学医学雑誌 61 (2), 19-27, 2009
鹿児島大学
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詳細情報 詳細情報について
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- CRID
- 1050001202754648704
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- NII論文ID
- 40016845619
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- NII書誌ID
- AN00040104
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- HANDLE
- 10232/14440
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- NDL書誌ID
- 10451398
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- ISSN
- 03685063
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- 本文言語コード
- en
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
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