NO-Rich Diet for Lifestyle-Related Diseases
抄録
type:text
Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases.
Open Access. This article belongs to the Special Issue Diet and Metabolic Dysfunction.
identifier:JOS-nu7064911
identifier:http://www.mdpi.com/journal/nutrients
収録刊行物
-
- Nutrients
-
Nutrients 7 (6), 4911-4937, 2015
MDPI AG
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1050001202797089664
-
- NII論文ID
- 120005704664
-
- ISSN
- 20726643
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- CiNii Articles