ラットを用いた非アルコール性脂肪性肝炎における肝臓のアミノ酸組成の変動

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  • Amino Acid Analysis of Non-alcoholic Steatohepatitis in Rat Liver
  • ラット オ モチイタ ヒアルコールセイ シボウセイ カンエン ニ オケル カンゾウ ノ アミノサン ソセイ ノ ヘンドウ

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Non-alcoholic steatohepatitis (NASH) is correlated with metabolic syndrome, and the prevalence of NASH patients is increasing worldwide. Fast food is considered a risk for the pathogenesis of NASH, so dietary therapy is very important for its prevention. In this study, amino acid composition of rat liver of NASH model was examined. WKY male rats (6 weeks old) were randomly divided into 8 groups. Control groups were fed control diets for 4 weeks, 8 weeks, 12 weeks and 16 weeks, respectively. HFC groups were fed high fat and high cholesterol diet for 4 weeks, 8 weeks, 12 weeks and 16 weeks, respectively. The liver weight of HFC group was high compared with control rat, and the surface color was whitish, indicating deposition of much lipid in the HFC liver. The cell pathology of liver was examined by transmission electron microscopy. Many lipid droplets were observed in the cytoplasm of hepatocyte, which increased after 8 week-intake of HFC diet. Amino acid analysis showed the increase of hydroxyproline in the liver of HFC group, while the other amino acids were decreased. Because hydroxyproline is a chief component of collagen molecules, the deposition of collagen fibrils in NASH liver has been confirmed by amino acid analysis.

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