A Basic Study of the Efficacy of the Dietary L-Arginine and Soy Isoflavone-Extracted on the Bone Metabolism in Ovariectomized Chronic Kidney Disease(CKD)Model Rats
Bibliographic Information
- Other Title
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- 〔研究ノート〕卵巣摘除された慢性腎臓病モデルラットの骨代謝維持に 対する食餌アルギニンあるいは大豆イソフラボン抽出物 投与の有効性評価に関する基礎的研究
- ランソウテキジョサレタ マンセイ ジンゾウビョウ モデルラット ノ ホネ タイシャ イジ ニ タイスル ショクジ アルギニン アルイハ ダイズ イソフラボン チュウシュツブツ トウヨ ノ ユウコウセイ ヒョウカ ニ カンスル キソテキ ケンキュウ
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Abstract
The present study was carried out to elucidate the protective effects of dietary L-arginine and soy isoflavone-extracted on the bone metabolism in the ovariectomized chronic kidney disease model rats. Nine-week-old female rats received 360mg/kg BW of adenine intragastrally for four consecutive days so that they would develop chronic kidney disease(CKD). After six days of recovery, rats received ovariectomies(OVX)under anesthesia. A sham operation was carried out on another group of rats(group Intact). Seven days after the OVX, the rats were given either a control diet(20% casein protein diet(group CA); 0.5% L-arginine supplemented diet(group Arg); or 0.20% soy isoflavone-extracted supplemented diet(group IF), 13g per day for 12 weeks. Rats in group Intact were, like group CA, given the control diet. The results were as follows: 1)Group CA developed moderate chronic kidney disease which was manifested as elevated kidney weight, increased serum creatinine, relatively lower creatinine clearance and reduced femoral-BMD than that of group Intact. 2)The L-Arginine supplemented diet did not improve renal function and femoral BMD-loss. But, increased mRNA expression levels of IGF-1, BMP-2 and Osterix were observed in the femurs. 3)Soy isoflavone-extracted supplemented diet had no preventative effects on BMD loss, although estrogen receptor-beta mRNA expression levels in the femurs were elevated. From these results, bone-protective functions of L-arginine via activation of osteoblast differentiation and bone formation process were suggested. Further investigation to clarify the efficacy of L-arginine-IGF-1 signal transduction on the bone metabolism is required to determine whether a therapy based on this approach can help people suffering from osteoporosis in CKD patients.
Journal
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- Gakuen
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Gakuen (914), 6-14, 2016-12-01
昭和女子大学近代文化研究所
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Details 詳細情報について
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- CRID
- 1050001202932048640
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- NII Article ID
- 120005903973
- 40021094691
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- NII Book ID
- AN00038441
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- ISSN
- 13480103
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- NDL BIB ID
- 027973190
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles