Epicatechins induce death of caco-2 colon cancer cells by raising the intracellular level of copper(II)

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タイトル別名
  • Epicatechins Induce Death of Caco-2 Colon Cancer Cells by Raising the Intracellular Level of Copper(2)
  • カテキン-銅イオンによる腸管上皮細胞株Caco-2の細胞死
  • カテキン ドウ イオン ニ ヨル チョウカン ジョウヒ サイボウカブ Caco-2 ノ サイボウシ

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説明

type:Departmental Bulletin Paper

We have recently shown that green tea epicatechins complexed with copper kill colon cancer cells of the Caco-2 line, in vitro, at concentrations for which copper alone does not affect cell viability.Attempting to elucidate the mechanism of killing, we found hereafter that epicatechms actively transport copper inside the cells promoting a prooxidant state eventually leading to apoptosis.

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