成熟期中期のラット足底筋に対する走トレーニングの影響

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  • セイジュクキ チュウキ ノ ラット ソクテイキン ニ タイスル ソウ トレーニング ノ エイキョウ
  • Effects of running training on the rat plantaris muscle during the middle maturation period

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We studied the effects of running training on myosin heavy chain (MyHC) isoform composition in 16 female mature Fischer 344 rats (12 month old). The animals were divided into two groups: sedentary (S; n = 7) or run (R; n = 9) group. Animals in the R group were trained with treadmill running (30 m/min， 60 min/day and 5 days/wk) for 8 weeks. After 8-weeks of training， the plantaris muscle (PLA) was isolated， and crude myosin was prepared. MyHC isoform composition was analyzed by sodium dodecyl sulfate polyaclylamidegel electrophoresis (SDS-PAGE). Body weights in both groups increased significantly during the training period. However， the final body weights of each group were not significantly different. PLA weight and relative PLA weight of the R group were significantly higher than those in the S group. No statistical difference was found in the compositions of the MyHC I and IId isoforms in either group. However， the R group value for the type IIa MyHC isoform was higher than that of the S group and the type IIb MyHC isoform value for the R group was relatively lower than that of the S group. These results indicated that the MyHC isoform composition of the PLA muscle changed with running training. We conclude that running training during the middle period of maturation affected muscle contractile protein metabolism.

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