前立腺腫瘍に対する凍結療法 --体液性免疫と尿流量測定による検討

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タイトル別名
  • CRYOSURGERY OF THE PROSTATE WITH REFERENCE TO CRYOIMMUNOLOGY AND UROFLOWMETRY
  • ゼンリツセン シュヨウ ニ タイスル トウケツ リョウホウ タイエキセイ メン

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It was Ablin et al. who stressed the production of species specific and tumor specific antibody was engendered following to the cryosurgical intervention. Some clinicians have brought forward considerable evidences to support Ablin's hypothesis. Clinical observations of patients treated cryosurgically for prostatic cancer have revealed instances of partial or complete remission of metastatic lesions. The levels of serum immunoglobulins, serum proteins, acid phosphatase, prostatic acid phosphatase alkaline phosphatase, lactic dehydrogenase and cholesterol in pa tien ts wi th prosta tic cancer were measured before and after the cryosurgery of prostate. Quantitative measurement of immunoglobulin in patients prior to cryotherapy disclosed a negligible difference between benign prostatic hypertrophy and prostatic cancer. Ablin et al. reported that decrease in α2-globulin and increases in r-globulin, IgM, IgG and IgA, have been observed following cryosurgery. But these results have not been obtained. Increases in IgG and γG were noted in 3 of 6 patients postoperatively. 4 of 8 patients with prostatic cancer had metastatic lesions, remissions of which have not been exhibited. Patients with prostatic cancer posses significantly elevated lebels of al-antitrypsin, levels of which and frequency of patients possessing significant elevation increased with a progression of the stage of their malignancy. Based on this finding, it is quite possible that al-antitrypsin is the prognostic potential applied to stage identification and clinical responsiveness. Postoperative changes in acid and alkaline phosphatase, LDH and cholesterol were not observed. The significance of cryoimmunology has not been assumed but its study presents intriguing field for research. Little work has been done to study uroflowmetry following to cryotherapy. There is considerable variation in complaints of dysuria of individual patients. Uroflowgrams were effective diagnostic methods to study the influence of cryotherapy on prostatism.

収録刊行物

  • 泌尿器科紀要

    泌尿器科紀要 23 (8), 791-799, 1977-11

    京都大学医学部泌尿器科学教室

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