慢性血液透析患者におけるC型肝炎ウイルス感染のサーベイランス

機関リポジトリ HANDLE Web Site

書誌事項

タイトル別名
  • マンセイ ケツエキ トウセキ カンジャ ニ オケル Cガタ カンエン ウイルス カンセン ノ サーベイランス
  • Surveillance of Hepatitis C Virus Infection in Hemodialysis Patient

この論文をさがす

抄録

In Japan, the rate of hepatitis C Virus (HCV) infection among hemodialysis patients is high (12.1%) ; yet, early detection of HCV infection among these patients is limited because their AST/ALT increase is small, an index or a standardized surveillance method is unavailable, the measurement of HCV antibody varies among facilities, and the conventional HCV-RNA test is costly. We applied the public HCV surveillance method to hemodialysis patients and examined its effectiveness. A total of 1,077 hemodialysis patient (690 males, 387 female ; mean age 59.8 ± 12.8 years old ; dialysis history 9.1 ± 6.0 years) were included. The public HCV surveillance method included a combination of HCV antibody, HCV core antigen, and HCV-RNA tests. Using this method, we detected 151 (14%) HCV antibody-positive patients, of whom the antibody was high in 89, medium in 50, and low in 12 patients. The conventional method would require all HCV antibody positive patients (n = 151) to undergo HCV-RNA test ; however, we only required 27 patients to undergo HCV-RNA test. The 82.1% reduction in the requirement for further testing shows that our method is cost effective and efficient. The surveillance method should be introduced to help reduce infection in hemodialysis patients.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ