Palladium-catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate and annulation of heteroarylamino-1-azaazulenes
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Abstract
The palladium catalyzed heteroarylamination of ethyl 2-chloro-1-azaazulene-3-carboxylate was achieved using a catalyst based on Pd2(dba)3 / Xantphos system. Treatment of ethyl 2-(heteroarylamino)-1-aza-azulene-3-carboxylates with a PPA-POCl3 mixture gave corresponding annulation products. 2-(2-Benzothiazolylamino)-1-azaazulene (3h) showed anticancer activity against HeLa S3 cells (IC50: 6.5 μM).
Journal
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- Heterocycles
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Heterocycles 79 (1), 319-324, 2009-04
日本複素環化学研究所
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Keywords
Details 詳細情報について
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- CRID
- 1050001337453234944
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- NII Article ID
- 120001316127
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- NII Book ID
- AA00663739
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- ISSN
- 03855414
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- NDL BIB ID
- 10204679
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- NDL
- CiNii Articles