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皮膚ランダム生検が診断に有用であった血管内リンパ腫の一例

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  • 症例報告 第6回若手奨励賞受賞論文 皮膚ランダム生検が診断に有用であった血管内リンパ腫の一例
  • ショウレイ ホウコク ダイ6カイ ワカテ ショウレイショウ ジュショウ ロンブン ヒフ ランダムセイケン ガ シンダン ニ ユウヨウ デ アッタ ケッカン ナイ リンパ シュ ノ イチレイ
  • A case of intravascular large B -cell lymphoma diagnosed by random skin biopsy
  • ヒフ ランダム セイケン ガ シンダン ニ ユウヨウ デ アッタ ケッカンナイ リンパシュ ノ イチレイ

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Abstract

A62‐year‐old woman was referred to our hospital for further examination of fever of unknown origin, splenomegaly and pancytopenia. On admission, she had persistent fever and psychological symptoms. Blood examination showed pancytopenia and elevated level of LDH, soluble IL‐2receptor and ferritin. Computed tomography showed multiple low density areas in the spleen, but no systemic lymphadenopathy. In magnetic resonance imaging of the pons, a low and high intensity area on T1‐and T2‐weighted image, respectively, was detected. Taken together these findings, she was suspected to have hepatosplentic T-cell lymphoma or intravascular large B-cell lymphoma. To make a definite diagnosis, random skin biopsy was performed. Immunohistochemical stainings revealed the massive infiltration of CD20‐and CD79α‐positive large lymphoid cells inside the vessels, which yielded the diagnosis of intravascular large B-cell lymphoma.

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