骨折を繰り返す疾患は骨肉腫の誘発因子となるか

辻, 香織, 原, 邦夫

骨折を繰り返す疾患は骨肉腫の誘発因子となるか

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コッセツオクリカエスシッカンワコツニクシュノユウハツインシトナルカ
Are repeated bone fracture diseases etiological factors of the development of osteosarcoma?

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Fracture has not been recognized as an etiological factor in the development of osteosarcoma. There have been rare reports of osteosarcoma developing after fracture, and the relationship between the fracture and subsequent osteosarcoma is uncertain. By reviewing papers and reports, we examined the incidence rate ratio of osteosarcoma development in four diseases with repeated bone fractures, including congenital insensitivity to pain with anhidrosis, pycnodysostosis, osteopetrosis and osteogenesis imperfect. As an open cohort study, the incidence rate ratio of osteosarcoma development in Japanese patients with repeated bone fractures was 10.7 times higher than that of Japanese population in 47 years. This result suggests that the diseases with repeated bone fracture may be an etiological factor in the development of osteosarcoma.