Low-dose radiation therapy for steroid resistant Kasabach-Merritt syndrome

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タイトル別名
  • ステロイド抵抗性Kasabach-Merritt症候群に対する低線量放射線治療
  • ステロイド テイコウセイ Kasabach-Merritt ショウコウグン ニ タイスル テイセンリョウ ホウシャセン チリョウ

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論文(Article)

From 1990 to 2001, a total of five hemangioma patients with Kasabach-Merritt syndrome received radiation therapy at Tohoku University Hospital. Steroids were administered before, during and after radiation therapy to all of the patients and interferon-α was administered to two patients. Radiation therapy was administered with a 4 MV X-ray was in four patients and a 12 MeV electron in one patient. Planned target volume included hemangioma with a 1-2 cm margin in all directions. A radiation dose of 3-3.5Gy was administered in 3-5 fractions. Rapid and transient increase of platelet count was observed in three patients. In two patients, an additional course of radiation was administered and the second course of radiation seemed to be effective for both. Of the three patients with hemangioma of the extremities, growth inhibition of irradiated extremities was not observed, and, in fact, elongation of extremities was observed in two patients. In one patient, lymphangioma developed from irradiated hemangioma. Although no serious late complications were observed in our series, 3-3.5Gy of radiation therapy for KMS seems to be insufficient to obtain rapid and stable improvement of thrombocytopenia.　Key words：Kasabach-Merritt syndrome, Radiation therapy, Low-dose

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