Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss

HANDLE Open Access

Abstract

A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1β levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.

Journal

  • FEBS Letters

    FEBS Letters 580 (5), 1251-1256, 2006-02-20

    Elsevier B.V.

Keywords

Details

  • CRID
    1050001338972149760
  • NII Article ID
    120000953646
  • HANDLE
    2115/5848
  • ISSN
    00145793
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB
    • CiNii Articles

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