Macrophage migration inhibitory factor-deficient mice are resistant to ovariectomy-induced bone loss
Description
A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1β levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.
Journal
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- FEBS Letters
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FEBS Letters 580 (5), 1251-1256, 2006-02-20
Elsevier B.V.
