実験的てんかんモデルにおける細胞性癌遺伝子c-fosの発現に関する研究

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  • The Expression of Proto-oncogene c-fos following Various Seizures in Mouse Brain

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Since c-fos is a transcriptional factor gene that is induced by various stimulations including dbc-AMP, Ca-influx, and phorbolester, it is thought to be a useful marker of neuronal activity in the nervous system. In the present study the anatomical distributions of c-fos mRNA expression were examined following various seizures including electroconvulsive shock, caffeine-induced seizures, kainate-induced seizures, and lidocaine-induced seizures. The distribution of c-fos mRNA expression was different between those seizures and was dependent on seizure induced mechanisms. Neuronal cell death following systemic kainate injection occurs in the discreet brain areas within the distributions where c-fos mRNA was induced following the treatment. However, dentate granule cells where c-fos mRNA was markedly observed are relatively strong. It will be of particular interest to analyze plastic change of neuronal cell in specific brain structures following those seizures at molecular levels.

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