Hyperglycemia in non‐obese patients with type 2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus
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- Hyperglycemia in non-obese patients with type2 diabetes is associated with low muscle mass: The Multicenter Study for Clarifying Evidence for Sarcopenia in Patients with Diabetes Mellitus
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AIMS/INTRODUCTION: Hyperglycemia is a risk factor for sarcopenia when comparing individuals with and without diabetes. However, no studies have investigated whether the findings could be extrapolated to patients with diabetes with relatively higher glycemic levels. Here, we aimed to clarify whether glycemic control was associated with sarcopenia in patients with type2 diabetes. MATERIALS AND METHODS: Study participants consisted of patients with type2 diabetes (n=746, the average age was 69.9years) and an older general population (n=2, 067, the average age was 68.2years). Sarcopenia was defined as weak grip strength or slow usual gait speed and low skeletal mass index. RESULTS: Among patients with type2 diabetes, 52 were diagnosed as having sarcopenia. The frequency of sarcopenia increased linearly with glycated hemoglobin (HbA1c) level, particularly in lean individuals (HbA1c <6.5%, 7.0%, ≥6.5% and <7.0%: 18.5%; HbA1c ≥7.0% and <8.0%: 20.3%; HbA1c ≥8.0%: 26.7%). The linear association was independent of major covariates, including anthropometric factors and duration of diabetes (HbA1c <6.5%: reference; ≥6.5% and <7.0%: odds ratio [OR] 4.38, P=0.030; HbA1c ≥7.0% and <8.0%: 4.29, P=0.024; HbA1c ≥8.0%: 7.82, P=0.003). HbA1c level was specifically associated with low skeletal mass index (HbA1c ≥8.0%: OR 5.42, P<0.001) rather than weak grip strength (OR 1.89, P=0.058) or slow gait speed (OR 1.13, P=0.672). No significant association was observed in the general population with a better glycemic profile. CONCLUSIONS: Poor glycemic control in patients with diabetes was associated with low muscle mass.
収録刊行物
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- Journal of diabetes investigation
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Journal of diabetes investigation 10 (6), 1471-1479, 2019-11
Wiley
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詳細情報 詳細情報について
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- CRID
- 1050004953483373952
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- NII論文ID
- 120006893973
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- ISSN
- 20401116
- 20401124
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- HANDLE
- 2433/255606
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
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