Regioselective Synthesis of 2,4-Differentially Arylated Pyrroles and Its Application to The Synthesis of Lamellarins

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An efficient method for the synthesis of 2,4-differentially arylated pyrroles has been developed via stepwise palladium-catalyzed Suzuki-Miyaura coupling of N-benzenesulfonyl-4-bromo-2-iodopyrrole with different arylboronic acids. This method has been applied to the new synthesis of the marine natural products lamellarins.

HETEROCYCLES, 93(2), pp.593-612; 2016

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  • HETEROCYCLES

    HETEROCYCLES 93 (2), 593-612, 2016

    日本複素環化学研究所

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