An innate interaction between IL-18 and the propeptide that inactivates its precursor form
Description
Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated intermolecularly using recombinant propeptide. These results suggest the possibility of developing a novel class of peptide-based IL-18 inhibitors that could serve as therapeutic agents for IL-18-related inflammatory diseases.
Journal
-
- Scientific Reports
-
Scientific Reports 9 6160-, 2019-04-16
Springer Nature
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1050006210048259840
-
- NII Article ID
- 120007006235
-
- ISSN
- 20452322
-
- HANDLE
- 2433/250006
-
- Text Lang
- en
-
- Article Type
- journal article
-
- Data Source
-
- IRDB
- Crossref
- CiNii Articles
- KAKEN