Pre and Post Synaptic Mechanisms about the Peripheral Nerve-injured Plasticity of Nociceptive Transmission in the Superficial Dorsal Horn of Mouse Spinal Cord

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Long-term potentiation（LTP）and long-term depression（LTD）in synaptic transmission have not only been observed in the hippocampus, but also in the superficial dorsal horn. LTP and LTD in the superficial dorsal horn play an important role of central sensitization, leading to hyperalgesia and allodynia in neuropathic pain. In order to clarify its mechanisms, we evaluated evoked excitatory postsynaptic currents（eEPSCs）and asynchronous EPSCs（aEPSCs）in the superficial dorsal horn of a sciatic nerve-ligated neuropathic pain mice（nerve-ligated mice）using whole cell patch clamp recording.Three types of neuron in the superficial dorsal horn of mouse spinal cord were observed after tetanus stimulation which were：eEPSC amplitude-increased（LTP neuron）, decreased（LTD neuron）and unchanged neurons. After tetanus stimulation, cumulative probability of aEPSCs amplitude did not change in LTP neuron, but shifted to the left in LTD neuron. In nerve-ligated mice, the ratio of LTP neuron was high. On the other hand, the ratio of both LTD neuron and unchanged neuron was high in sham-operated control mice.These findings suggest both pre- and post-synaptic mechanisms of central sensitization in the superficial dorsal horn may contribute to neuropathic pain and LTP or LTD may be important role of pre- or postsynaptic action, respectively.

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詳細情報 詳細情報について

  • CRID
    1050006697132538752
  • NII論文ID
    120007040036
  • NII書誌ID
    AA00629581
  • ISSN
    03855023
  • Web Site
    http://id.nii.ac.jp/1199/00002462/
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • CiNii Articles
    • KAKEN

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