腎疾患に於ける血清脂質に関する臨床的研究

機関リポジトリ Web Site

書誌事項

タイトル別名
  • ジンシッカン ニ オケル ケッセイ シシツ ニ カンスル リンショウテキ ケンキュウ
  • Clinical Studies on Serum Lipids
  • 原著
  • Original Article
公開日
1960-09-28
資源種別
journal article
公開者
千葉医学会

この論文をさがす

説明

type:text

To investigate the relationship between serum lipids and various serum proteins in kidney disease, serum lipid levels were made to determine and the characteristic pattern of serum protein fractions was analyzed in 51 patients with kidney disease. (These fiftyone patients are 51 cases of glomerular nephritis and 16 cases of nephrotic syndrome.) Glomerular nephritis was associated with mild disturbances of lipid and protein metabolism, although analysis failed to establish any difinite relationships between the two. From the standpoint of the degree of kidney disturbances, total cholesterol tended to increase with aggravation of kidney function in chronic nephritis. In nephrotic syndrome, however, disturbances of lipid and protein metabolism were found to be very severe and serum lipid was remarkably increased in many cases, but normal value were found to be present in some cases in convalescence ; therefore, the fluctuation was considerably great during the course of the disease. The increase of total cholesterol with a marked disturbance of kidney function was found to be not as great in severe cases as those suffering from mild disturbances of kidney function, with none of the cases showing normal values throughout the course of their illoess. Furthermore, ratio of high degree was found to be present in the almost all cases. Paper electrophorosis of the serum from the patients with nephrotic syndrome revealed a characteristic pattern of protein fractions : albumin was markedly decreased, α_2-globulin and β-globulin were markedly increased, α-globulin was decreased. In glycoprotein fractions α_2-globulin was remarkably increased, while β-fraction and the ratio of β/α showed considerably increase in lipoprotein and phospholipid fractions. These various changes of protein were related to the increase of serum lipid and the relationship was confirmed by clinical cases.

収録刊行物

詳細情報 詳細情報について

問題の指摘

ページトップへ