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  • HER2 ヨウセイ ニュウガン カンジャ ニ オケル ジュツゼン カガク リョウホウ カイシ マエ ノ ソウ リンパキュウスウ ワ ヨゴ ヨソク ノ シヒョウ ト ナリ エル
  • Absolute lymphocyte count changes during neoadjuvant chemotherapy are associated with prognosis of HER2-positive breast cancer patients
  • HER2陽性乳癌の総リンパ球数の検討

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Purpose : Several studies have shown that peripheral hematologic parameters, such as the absolute lymphocyte count(ALC)and neutrophil to lymphocyte ratio(NLR)can predict the prognosis for malignant tumor. We investigated the relation of these parameter and prognosis before neoadjuvant chemotherapy for human epidermal growth factor receptor-2(HER2)-positive breast cancer patients. Methods : From April 2009 to March 2019, 85 patients diagnosed with HER2‐positive breast cancer and treated with trastuzumab-based neoadjuvant chemotherapy were included in this retrospective cohort study. The optimal cut-off for the NLR and ALC was identified using the receiver operating characteristic(ROC)curve analysis and Youden’s index. Results : The median age of patients at the start of treatment was 58.9(range 32‐81)years. The median follow-up time for HER2-positive breast cancer patients was 52.0(range:9.8‐114.3)months. In this period, 11 patients developed recurrence. The low-ALC group showed better disease free survival than the high-ALC group(p=0.0482). There was no significant difference in disease free survival between the low- and high-NLR groups. Conclusion : ALC before neoadjuvant chemotherapy may be a predictor of prolonged disease free survival in HER2‐positive breast cancer patients.


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