動物種により異なる腸管におけるヒスタミン応答

書誌事項

タイトル別名
  • ドウブツシュ ニ ヨリ コトナル チョウカン ニ オケル ヒスタミン オウトウ
  • Histamine Responses on Gut were different by Animal Species

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抄録

In order to study about agonist/antagonist by using acetylcholine (ACh), atropine (Atr), and histamine (His) on excised small intestine, guinea pig has been generally used as experimental animal. The present study measured intestinal contraction by ACh/Atr/His on mice and discussed the possibility of replacement of experimental animal from guinea pigs to mice. Contraction by His on mice could be obtained only at the lower part of mice ileum. So, at the present, it might be not good to use mice for this experiment.

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