14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice

  • 横井, 紀彦
    Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies)
  • 深田, 優子
    Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies)
  • 尾勝, 圭
    Department of Chemistry, Graduate School of Science, Kyoto University
  • 山形, 敦史
    RIKEN Center for Biosystems Dynamics Research
  • 劉, 岩
    Department of Chemistry, Graduate School of Science, Kyoto University
  • 三宝, 誠
    Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences
  • 宮﨑, 裕理
    Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies)
  • 後藤, 哲平
    Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences
  • 阿部, 学
    Department of Animal Model Development, Brain Research Institute, Niigata University
  • 葛西, 秀俊
    Laboratory of Animal Resources, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
  • 崎村, 建司
    Department of Animal Model Development, Brain Research Institute, Niigata University
  • Meijer, Dies
    Centre for Discovery Brain Sciences, University of Edinburgh
  • 平林, 真澄
    Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies); Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences
  • 深井, 周也
    Department of Chemistry, Graduate School of Science, Kyoto University
  • 深田, 正紀
    Division of Membrane Physiology, Department of Molecular and Cellular Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies)

抄録

新たなてんかん治療戦略を提案 --脳の過剰興奮を阻止するタンパク質ADAM22の量が鍵--. 京都大学プレスリリース. 2021-12-15.

収録刊行物

  • Cell Reports

    Cell Reports 37 (11), 110107-, 2021-12

    Elsevier BV

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