Total Synthesis of Dictyodendrins A–F by the Gold‐Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole

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The total synthesis of dictyodendrins A–F was achieved using the gold(I)-catalyzed annulation of a conjugated diyne with NBoc-pyrrole for direct construction of the pyrrolo[2, 3-c]carbazole scaffold. Late-stage functionalization of the resulting pyrrolo[2, 3-c]carbazole to introduce various substituents provided divergent access to dictyodendrins. Some dictyodendrin analogues exhibited inhibitory activities toward CDK2/CycA2 and GSK3.

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