A computational model based on corticospinal functional MRI revealed asymmetrically organized motor corticospinal networks in humans

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  • 高澤, 英嗣
    Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry; Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine
  • 阿部, 十也
    Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry
  • 筑田, 博隆
    Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine
  • 花川, 隆
    Department of Advanced Neuroimaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry; Department of Integrated Neuroanatomy & Neuroimaging, Kyoto University Graduate School of Medicine
  • 阿部, 十也
  • 高澤, 英嗣
  • 筑田, 博隆
  • 花川, 隆

書誌事項

公開日
2022
資源種別
journal article
権利情報
  • © The Author(s) 2022
  • This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
DOI
  • 10.1038/s42003-022-03615-2
公開者
Springer Nature

説明

Evolution of the direct, monosynaptic connection from the primary motor cortex to the spinal cord parallels acquisition of hand dexterity and lateralization of hand preference. In non-human mammals, the indirect, multi-synaptic connections between the bilateral primary motor cortices and the spinal cord also participates in controlling dexterous hand movement. However, it remains unknown how the direct and indirect corticospinal pathways work in concert to control unilateral hand movement with lateralized preference in humans. Here we demonstrated the asymmetric functional organization of the two corticospinal networks, by combining network modelling and simultaneous functional magnetic resonance imaging techniques of the brain and the spinal cord. Moreover, we also found that the degree of the involvement of the two corticospinal networks paralleled lateralization of hand preference. The present results pointed to the functionally lateralized motor nervous system that underlies the behavioral asymmetry of handedness in humans.

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