Identification of CD4 and H-2K(d)-restricted cytotoxic T lymphocyte epitopes on the human herpesvirus 6B glycoprotein Q1 protein
説明
The identification of Human herpesvirus 6B (HHV-6B) epitopes that are recognized by T-cells could contribute to the development of potential vaccines and immunotherapies. Here, we identified CD4(+) and H-2K(d)-restricted CD8(+) T-cell epitopes on the glycoprotein Q1 of HHV-6B (BgQ1), which is a unique glycoprotein and essential for HHV-6B viral entry, by using in vivo electroporation with a plasmid DNA encoding BgQ1, overlapping peptides spanning the BgQ1 sequence, ELISPOT assay for quantification of gamma interferon (IFN-γ), and computer-based T-cell epitope prediction programs. The CD4(+) and CD8(+) T-cell epitopes identified in BALB/c mice in this study could be a good animal model system for use in the development of T-cell responses, inducing HHV-6B vaccines or immunotherapies.
収録刊行物
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- Scientific Reports
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Scientific Reports 9 3911-3911, 2019-03-07
Nature Research
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詳細情報 詳細情報について
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- CRID
- 1050012570393066880
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- NII論文ID
- 120006599164
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- ISSN
- 20452322
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- HANDLE
- 20.500.14094/90005720
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- CiNii Articles
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- OpenAIRE
