アミオダロン角膜症発症に及ぼす涙液動態の影響

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  • アミオダロン カクマクショウ ハッショウ ニ オヨボス ルイエキ ドウタイ ノ エイキョウ
  • The connection of the tear function of the patients with Amiodarone keratopathy

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Abstract

Purpose: Amiodarone keratopayhy is thorgt to be caused by the deposition of Amiodarone to a lacrimal gland. In the present study, we examined the connection of the tear finction of the patients with Amiodarone keratopathy. Method: Twenty-four eyes of 12 patients (9 male, and 3 female). whose follow-up period was longer than 3 weeks after the use of Amiodarone were recruited to this study. Amiodarone keratopathy was graded using Orlando classification. Schirmer test, BUT measurement and tear film lipid layer interferometry (DR-1) were performed as tear function tests. Result: The period of the onset of keratopathy, and the stage of orlando classification were not obviously correlated with each tear function test. Howerver 20 eyes (83.3%) showed Grade III and higher in DR-1, 19 eyes (79.2%) showed less than 5 sec in BUT or less than 5.0mm in Schirmer test value. There is no obvious correlation between, and each tears examination, but in 20 eyes (83.3%) DR-1 showed more than Grade III, and in a 19 eyes (79.2%) BUT showed less than 5.0 second nor Schirmer value less than 5.0mm. Conclusion: Patients with Amiodarone keratopathy showed high tendency of dry eye.

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