Stiffness of primordial germ cells is required for their extravasation in avian embryos
-
- 齋藤, 大介
- Frontier Research Institute for Interdisciplinary Sciences, Tohoku University; Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University; Department of Biology, Faculty of Science, Kyushu University
-
- 田所, 竜介
- Department of Zoology, Graduate School of Science, Kyoto University; Department of Bioscience, Okayama University of Science
-
- 長坂, 新
- Division of Histology, Meikai University School of Dentistry; Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
-
- 吉野, 大輔
- Frontier Research Institute for Interdisciplinary Sciences, Tohoku University; Institute of Engineering, Tokyo University of Agriculture and Technology
-
- 寺本, 孝行
- Department of Biology, Faculty of Science, Kyushu University
-
- 水本, 堪大
- Department of Zoology, Graduate School of Science, Kyoto University
-
- 船本, 健一
- Institute of Fluid Science, Tohoku University
-
- 城所, 比奈子
- Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University; Organization for Research Initiatives and Development, Doshisha University
-
- 宮田, 卓樹
- Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine
-
- 田村, 宏治
- Department of Ecological Developmental Adaptability Life Sciences, Graduate School of Life Sciences, Tohoku University
-
- 高橋, 淑子
- Department of Zoology, Graduate School of Science, Kyoto University
説明
Unlike mammals, primordial germ cells (PGCs) in avian early embryos exploit blood circulation to translocate to the somatic gonadal primordium, but how circulating PGCs undergo extravasation remains elusive. We demonstrate with single-cell level live-imaging analyses that the PGCs are arrested at a specific site in the capillary plexus, which is predominantly governed by occlusion at a narrow path in the vasculature. The occlusion is enabled by a heightened stiffness of the PGCs mediated by actin polymerization. Following the occlusion, PGCs reset their stiffness to soften in order to squeeze through the endothelial lining as they transmigrate. Our discovery also provides a model for the understanding of metastasizing cancer extravasation occurring mainly by occlusion.
収録刊行物
-
- iScience
-
iScience 25 (12), 105629-, 2022-12-22
Elsevier BV
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1050013010132890880
-
- ISSN
- 25890042
-
- HANDLE
- 2433/277820
-
- PubMed
- 36465120
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- Crossref
- KAKEN
- OpenAIRE
