Optogenetic Therapy for Visual Restoration
説明
Optogenetics is a recent breakthrough in neuroscience, and one of the most promising applications is the treatment of retinal degenerative diseases. Multiple clinical trials are currently ongoing, less than a decade after the first attempt at visual restoration using optogenetics. Optogenetic therapy has great value in providing hope for visual restoration in late-stage retinal degeneration, regardless of the genotype. This alternative gene therapy consists of multiple elements including the choice of target retinal cells, optogenetic tools, and gene delivery systems. Currently, there are various options for each element, all of which have been developed as a product of technological success. In particular, the performance of optogenetic tools in terms of light and wavelength sensitivity have been improved by engineering microbial opsins and applying human opsins. To provide better post-treatment vision, the optimal choice of optogenetic tools and effective gene delivery to retinal cells is necessary. In this review, we provide an overview of the advancements in optogenetic therapy for visual restoration, focusing on available options for optogenetic tools and gene delivery methods.
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 23 (23), 15041-, 2022-12
MDPI
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キーワード
詳細情報 詳細情報について
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- CRID
- 1050013087466751616
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- ISSN
- 14220067
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- HANDLE
- 20.500.14094/0100477955
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB