Dopamine error signal to actively cope with lack of expected reward

石野, 誠也, 鎌田, 泰輔, サポン, ギデオン, 北野, 樹里亜, 司, 玲央, 向平, 妃沙, サン, ファンミャオ, リ, ユーロン, 小林, 憲太, 本田, 直樹, 大石, 直也, 小川, 正晃

doi:10.21203/rs.3.rs-1391246/v1

To obtain more of a particular uncertain reward, animals must learn to actively overcome the lack of reward and adjust behavior to obtain it again. The neural mechanisms underlying such coping with reward omission remain unclear. Here, we developed a task in rats to monitor active behavioral switch toward the next reward after no reward. We found that some dopamine neurons in the ventral tegmental area exhibited increased responses to unexpected reward omission and decreased responses to unexpected reward, following the opposite responses of the well-known dopamine neurons that signal reward prediction error (RPE). The dopamine increase reflected in the nucleus accumbens correlated with behavioral adjustment to actively overcome unexpected no reward. We propose that these responses signal error to actively cope with lack of expected reward. The dopamine error signal thus cooperates with the RPE signal, enabling adaptive and robust pursuit of uncertain reward to ultimately obtain more reward.

Dopamine error signal to actively cope with lack of expected reward

説明

収録刊行物

被引用文献 (1)*注記

参考文献 (59)*注記

関連プロジェクト

キーワード

詳細情報詳細情報について

書き出し

問題の指摘

Dopamine error signal to actively cope with lack of expected reward

説明

収録刊行物

被引用文献 (1)*注記

参考文献 (59)*注記

関連プロジェクト

キーワード

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について