Case report: Immunological characteristics of de novo ulcerative colitis in a child post COVID-19
抄録
<jats:p>The pathological mechanisms of <jats:italic>de novo</jats:italic> inflammatory bowel disease (IBD) following SARS-CoV-2 infection are unknown. However, cases of coexisting IBD and multisystem inflammatory syndrome in children (MIS-C), which occurs 2–6 weeks after SARS-CoV-2 infection, have been reported, suggesting a shared underlying dysfunction of immune responses. Herein, we conducted the immunological analyses of a Japanese patient with <jats:italic>de novo</jats:italic> ulcerative colitis following SARS-CoV-2 infection based on the pathological hypothesis of MIS-C. Her serum level of lipopolysaccharide-binding protein, a microbial translocation marker, was elevated with T cell activation and skewed T cell receptor repertoire. The dynamics of activated CD8<jats:sup>+</jats:sup> T cells, including T cells expressing the gut-homing marker α4β7, and serum anti-SARS-CoV-2 spike IgG antibody titer reflected her clinical symptoms. These findings suggest that SARS-CoV-2 infection may trigger the <jats:italic>de novo</jats:italic> occurrence of ulcerative colitis by impairing intestinal barrier function, T cell activation with a skewed T cell receptor repertoire, and increasing levels of anti-SARS-CoV-2 spike IgG antibodies. Further research is needed to clarify the association between the functional role of the SARS-CoV-2 spike protein as a superantigen and ulcerative colitis.</jats:p>
収録刊行物
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- Frontiers in Immunology
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Frontiers in Immunology 14 1107808-, 2023-02
Frontiers Media
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詳細情報 詳細情報について
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- CRID
- 1050014591531745024
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- ISSN
- 16643224
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- HANDLE
- 2241/0002006965
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- KAKEN