The first Japanese biobank of patient‐derived pediatric acute lymphoblastic leukemia xenograft models
この論文をさがす
抄録
A lack of practical resources in Japan has limited preclinical discovery and testing of therapies for pediatric relapsed and refractory acute lymphoblastic leukemia (ALL), which has poor outcomes. Here, we established 57 patient-derived xenografts (PDXs) in NOD.Cg-Prkdcscidll2rgtm1Sug/ShiJic (NOG) mice and created a biobank by preserving PDX cells including three extramedullary relapsed ALL PDXs. We demonstrated that our PDX mice and PDX cells mimicked the biological features of relapsed ALL and that PDX models reproduced treatment-mediated clonal selection. Our PDX biobank is a useful scientific resource for capturing drug sensitivity features of pediatric patients with ALL, providing an essential tool for the development of targeted therapies.
収録刊行物
-
- Cancer Science
-
Cancer Science 113 (11), 3814-3825, 2022-11
Wiley
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1050014868313288064
-
- ISSN
- 13497006
- 13479032
-
- HANDLE
- 2433/283090
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- IRDB
- Crossref
- KAKEN