Clinical characteristics and factors related to infection with SCCmec type II and IV Methicillin-resistant Staphylococcus aureus in a Japanese secondary care facility: a single-center retrospective study

HANDLE Open Access
  • Nakano, Yuki
    Department of Environmental Medicine and Infectious Disease, Kyushu University Department of Pharmacy, Saiseikai Futsukaichi Hospital
  • Murata, Masayuki
    Department of Environmental Medicine and Infectious Disease, Kyushu University Department of General Internal Medicine, Kyushu University Center for the Study of Global Infection, Kyushu University Hospital
  • Matsumoto, Yuji
    Department of Environmental Medicine and Infectious Disease, Kyushu University Department of General Internal Medicine, Kyushu University Center for the Study of Global Infection, Kyushu University Hospital
  • Toyoda, Kazuhiro
    Department of General Internal Medicine, Kyushu University Hospital Center for the Study of Global Infection, Kyushu University Hospital
  • Ota, Azusa
    Department of Environmental Medicine and Infectious Disease, Kyushu University Center for the Study of Global Infection, Kyushu University Hospital
  • Yamasaki, Sho
    Department of Environmental Medicine and Infectious Disease, Kyushu University Department of General Internal Medicine, Kyushu University
  • Otakeno, Hisao
    Department of Pharmacy, Saiseikai Futsukaichi Hospital
  • Yokoo, Kenjo
    Department of Pharmacy, Saiseikai Futsukaichi Hospital
  • Shimono, Nobuyuki
    Department of General Internal Medicine, Kyushu University Hospital Center for the Study of Global Infection, Kyushu University Hospital

Abstract

Objectives: Differences in virulence genes, including psm-mec , which is a phenol-soluble modulin-mec (PSM-mec) encoding gene, of predominant staphylococcal cassette chromosome mec (SCCmec) types II and IV Methicillin-resistant Staphylococcus aureus (MRSA) may contribute to the virulence and clinical features of MRSA in Japan. We aimed to clarify the clinical characteristics and risk factors of infection among SCCmec types II and IV MRSA isolates from a Japanese secondary acute care hospital. / Methods: We analysed 58 SCCmec type II and 83 SCCmec type IV MRSA isolates collected from blood, central venous catheter tips, deep or superficial tissues, and sputum. / Results: SCCmec type II MRSA risk factors for progression to infection were seb , enterotoxin gene cluster, psm-me c mutation, and vancomycin minimum inhibitory concentrations (MIC) of 1 or 2 mg/L as viru- lence factors (adjusted odds ratio [aOR] = 11.8; 95% confidence interval [CI]: 2.49–77.7; P = 0.004); solid tumour was a host factor (aOR = 25.9; 95% CI: 3.66–300; P = 0.003). SCCmec type IV MRSA risk fac- tors were sea, cna , and vancomycin MIC of 1 or 2 mg/L as virulence factors (aOR = 3.14; 95% CI: 1.06–10.6; P = 0.049) and intravascular indwelling catheter as host factors (aOR = 3.78; 95% CI: 1.03–14.5; P = 0.045). Compared with SCCmec type II, SCCmec type IV MRSA resulted in more frequent bloodstream infections and higher Sequential Organ Failure Assessment scores. / Conclusion: We found that factors related to virulence genes and bacteriological and host characteristics are associated with SCCmec types II and IV MRSA infection and severity. These risk factors may be useful criteria for designing infection control programs.

Journal

Details 詳細情報について

  • CRID
    1050017057726557056
  • ISSN
    22137173
    22137165
  • HANDLE
    2324/6630995
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB

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