Clinical characteristics and factors related to infection with SCCmec type II and IV Methicillin-resistant Staphylococcus aureus in a Japanese secondary care facility: a single-center retrospective study

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  • 中野, 祐樹
    九州大学大学院感染制御医学 福岡県済生会二日市病院薬剤部
  • 村田, 昌之
    九州大学病院感染制御医学 九州大学病院総合診療科 九州大学病院グローバル感染症センター
  • 松本, 佑慈
    九州大学病院感染制御医学 九州大学病院総合診療科 九州大学病院グローバル感染症センター
  • 豊田, 一弘
    九州大学病院総合診療科 九州大学病院グローバル感染症センター
  • 太田, 梓
    九州大学病院感染制御医学 九州大学病院グローバル感染症センター
  • 山嵜, 奨
    九州大学大学院感染制御医学 九州大学病院総合診療科
  • 大竹野, 久雄
    福岡県済生会二日市病院薬剤部
  • 横尾, 賢乗
    福岡県済生会二日市病院薬剤部
  • 下野, 信行
    九州大学病院総合診療科 九州大学病院グローバル感染症センター

抄録

Objectives: Differences in virulence genes, including psm-mec , which is a phenol-soluble modulin-mec (PSM-mec) encoding gene, of predominant staphylococcal cassette chromosome mec (SCCmec) types II and IV Methicillin-resistant Staphylococcus aureus (MRSA) may contribute to the virulence and clinical features of MRSA in Japan. We aimed to clarify the clinical characteristics and risk factors of infection among SCCmec types II and IV MRSA isolates from a Japanese secondary acute care hospital. / Methods: We analysed 58 SCCmec type II and 83 SCCmec type IV MRSA isolates collected from blood, central venous catheter tips, deep or superficial tissues, and sputum. / Results: SCCmec type II MRSA risk factors for progression to infection were seb , enterotoxin gene cluster, psm-me c mutation, and vancomycin minimum inhibitory concentrations (MIC) of 1 or 2 mg/L as viru- lence factors (adjusted odds ratio [aOR] = 11.8; 95% confidence interval [CI]: 2.49–77.7; P = 0.004); solid tumour was a host factor (aOR = 25.9; 95% CI: 3.66–300; P = 0.003). SCCmec type IV MRSA risk fac- tors were sea, cna , and vancomycin MIC of 1 or 2 mg/L as virulence factors (aOR = 3.14; 95% CI: 1.06–10.6; P = 0.049) and intravascular indwelling catheter as host factors (aOR = 3.78; 95% CI: 1.03–14.5; P = 0.045). Compared with SCCmec type II, SCCmec type IV MRSA resulted in more frequent bloodstream infections and higher Sequential Organ Failure Assessment scores. / Conclusion: We found that factors related to virulence genes and bacteriological and host characteristics are associated with SCCmec types II and IV MRSA infection and severity. These risk factors may be useful criteria for designing infection control programs.

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詳細情報 詳細情報について

  • CRID
    1050017057726557056
  • ISSN
    22137173
    22137165
  • HANDLE
    2324/6630995
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB

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