ラット後肢ギプス固定におけるCross-Educationが骨格筋に及ぼす影響

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  • Effects of Cross-Education on Skeletal Muscles of Cast-Immobilized Hindlimb Leg in Rats

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Cross-education is defined as the performance improvement in the untrained limb after unilateral exercise training. We investigated whether cross-education action prevents muscle atrophy during casted-immobilization in rat hindlimb muscles. Adult male F344 rats were assigned to unilateral immobilization control（IM）and unilateral immobilization with exercise（IMEX）groups. The right hindlimb of the rat in both groups was fixed in a natural position with a cast. Rats of the IMEX group performed an isometric contraction exercise in which the body was supported in an inclined tube. After two weeks of immobilization and exercise, the hindlimb muscles were removed and the muscle weights were compared. In both groups, hindlimb muscle mass on the immobilized side was decreased compared to the free side. The relative weights of most muscles on the immobilized side were higher in the IMEX group than in the IM group. However, in the slow-twitch soleus muscle, no differences in the relative weight of the immobilized side were observed between the two groups. These results suggested that cross-education action may prevent muscle atrophy during casted immobilization and that its action differs among skeletal muscles.

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