Synthesis of ω-Chloroalkyl Aryl Ketones via C–C Bond Cleavage of tert-Cycloalkanols with Tetramethylammonium Hypochlorite
説明
An oxidative C–C bond cleavage of tert-cycloalkanols with tetramethylammonium hypochlorite (TMAOCl) has been developed. TMAOCl is easy to prepare from tetramethylammonium hydroxide, and the combination of TMAOCl and AcOH effectively promoted the C–C bond cleavage in a two-phase system without additional phase-transfer reagents. Unstrained tert-cycloalkanols were transformed into ω-chloroalkyl aryl ketones in moderate to excellent yields under metal-free and mild reaction conditions.
収録刊行物
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- Molecules
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Molecules 29 (8), art. no. 1874-, 2024-04-19
MDPI
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キーワード
詳細情報 詳細情報について
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- CRID
- 1050018616983423744
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- ISSN
- 14203049
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- HANDLE
- 10069/0002000815
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB