Effect of Periodontal Treatment on Reducing Chronic Inflammation in Systemically Healthy Patients With Periodontal Disease

HANDLE Open Access
  • Matsuda, Shinji
    Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Shintani, Tomoaki
    Center of Oral Clinical Examination
  • Miyagawa, Tsuyoshi
    Clinical Research Center in Hiroshima, Hiroshima University Hospital
  • Yumoto, Hiromichi
    Department of Periodontology and Endodontology, Institute of Biomedical Sciences, Tokushima University Graduate school
  • Komatsu, Yasutaka
    Periodontal Clinic, Niigata University, Medical and Dental Hospital
  • Dewake, Nanae
    Department of Operative Dentistry, Endodontology and Periodontology, School of Dentistry, Matsumoto Dental University
  • Iwata, Takanori
    Department of Periodontology, Tokyo Medical and Dental University
  • Nagano, Takatoshi
    Department of Periodontology, Tsurumi University School of Dental Medicine
  • Morozumi, Toshiya
    Department of Periodontology, Faculty of Dentistry, Kanagawa Dental University
  • Goto, Ryoma
    Department of Periodontology, School of Dentistry, Aichi Gakuin University
  • Kato, Satsuki
    Health Sciences University of Hokkaido, School of Dentistry, Division of Periodontology and Endodontology, Department of Oral Rehabilitation
  • Kitamura, Masahiro
    Graduate School of Dentistry, Department of Periodontology and Regenerative Dentistry, Osaka University
  • Shin, Kitetsu
    Division of Periodontology, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry
  • Sekino, Satoshi
    School of Life Dentistry Department of Periodontology, The Nippon Dental University
  • Yamashita, Akiko
    Section of Periodontology, Division of Oral Rehabilitation Faculty of Dental Science, Kyushu University
  • Yamashita, Keiko
    Department of Periodontology, Tokyo Dental College
  • Yoshimura, Atsutoshi
    Department of Periodontology and Endodontology, Nagasaki University Graduate School of Biomedical Sciences
  • Sugaya, Tsutomu
    Department of Periodontology and Endodontology, Faculty of Dental Medicine, Hokkaido University
  • Takashiba, Shogo
    Department of Pathophysiology-Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
  • Taguchi, Yoichiro
    Faculty of Dentistry, Department of Periodontology, Osaka Dental University
  • Nemoto, Eiji
    Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry
  • Nishi, Hiromi
    Department of General Dentistry, Hiroshima University Hospital
  • Mizuno, Noriyoshi
    Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Numabe, Yukihiro
    School of Life Dentistry Department of Periodontology, The Nippon Dental University
  • Kawaguchi, Hiroyuki
    Department of General Dentistry, Hiroshima University Hospital

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Description

Background: / We determined the effects and an accurate marker of periodontal treatment on serum interleukin (IL)-6 and high-sensitivity C-reactive protein (HsCRP) levels in systemically healthy individuals with periodontal disease. / Methods: / This multicenter study included systemically healthy individuals with periodontal disease who received initial periodontal treatment and had no periodontal treatment history. Periodontal parameters, including periodontal inflamed surface area, masticatory efficiency, and periodontal disease classification; serum IL-6 and HsCRP levels; and serum immunoglobulin (Ig)G titers against periodontal pathogens were evaluated at baseline and after treatment. Subjects were classified as low or high responders (group) based on periodontal inflamed surface area changes. / Results: / There were 153 participants. Only periodontal inflamed surface area changes were markedly different between low and high responders. Periodontal treatment (time point) decreased both serum IL-6 and HsCRP levels. The interaction between group and time point was remarkable only for serum IL-6 levels. Changes in serum immunoglobulin (Ig)G titers against periodontal pathogens were not associated with IL-6 changes in high responders. We analyzed the indirect effect of serum anti-Porphyromonas gingivalis type 2 IgG titer changes using mediation analysis and found no significance. However, the direct effect of group (low or high responder) on IL-6 changes was considerable. / Conclusions: / Periodontal treatment effectively decreased serum IL-6 levels, independent of periodontal pathogen infection, in systemically healthy individuals with periodontal disease.

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Details 詳細情報について

  • CRID
    1050019204192470400
  • NII Book ID
    AA00520786
  • ISSN
    15557162
    00029343
  • HANDLE
    2324/7183038
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB

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