Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

HANDLE HANDLE Open Access
  • Tamura, Tomokazu
    Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University Graduate School of Medicine, Hokkaido University School of Medicine, Hokkaido University Institute for the Advancement of Higher Education, Hokkaido University Institute for Vaccine Research and Development (IVReD), Hokkaido University One Health Research Center, Hokkaido University
  • Irie, Takashi
    Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Deguchi, Sayaka
    Center for iPS Cell Research and Application (CiRA), Kyoto University
  • Yajima, Hisano
    Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University
  • Tsuda, Masumi
    Department of Cancer Pathology, Faculty of Medicine, Hokkaido University Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
  • Nasser, Hesham
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University Department of Clinical Pathology, Faculty of Medicine, Suez Canal University
  • Mizuma, Keita
    Institute for Vaccine Research and Development (IVReD), Hokkaido University Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University
  • Plianchaisuk, Arnon
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Suzuki, Saori
    Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University Graduate School of Medicine, Hokkaido University School of Medicine, Hokkaido University Institute for Vaccine Research and Development (IVReD), Hokkaido University
  • Uriu, Keiya
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo Graduate School of Medicine, The University of Tokyo
  • Begum, Mst Monira
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Shimizu, Ryo
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Jonathan, Michael
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Suzuki, Rigel
    Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University Graduate School of Medicine, Hokkaido University School of Medicine, Hokkaido University Institute for Vaccine Research and Development (IVReD), Hokkaido University
  • Kondo, Takashi
    School of Medicine, Hokkaido University
  • Ito, Hayato
    Graduate School of Medicine, Hokkaido University
  • Kamiyama, Akifumi
    Graduate School of Medicine, Hokkaido University
  • Yoshimatsu, Kumiko
    Institute for Genetic Medicine, Hokkaido University
  • Shofa, Maya
    Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki Graduate School of Medicine and Veterinary Medicine, University of Miyazaki
  • Hashimoto, Rina
    Center for iPS Cell Research and Application (CiRA), Kyoto University
  • Anraku, Yuki
    Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Terakado Kimura, Kanako
    Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University
  • Kita, Shunsuke
    Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University
  • Sasaki, Jiei
    Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University
  • Sasaki-Tabata, Kaori
    Department of Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University
  • Maenaka, Katsumi
    One Health Research Center, Hokkaido University Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University Division of Pathogen Structure, International Institute for Zoonosis Control, Hokkaido University Global Station for Biosurfaces and Drug Discovery, Hokkaido University
  • Nao, Naganori
    Institute for Vaccine Research and Development (IVReD), Hokkaido University One Health Research Center, Hokkaido University Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University
  • Wang, Lei
    Department of Cancer Pathology, Faculty of Medicine, Hokkaido University Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
  • Oda, Yoshitaka
    Department of Cancer Pathology, Faculty of Medicine, Hokkaido University
  • The Genotype to Phenotype Japan (G2P-Japan) Consortium
  • Sawa, Hirofumi
    Institute for Vaccine Research and Development (IVReD), Hokkaido University One Health Research Center, Hokkaido University Division of International Research Promotion, International Institute for Zoonosis Control, Hokkaido University Division of Molecular Pathobiology, International Institute for Zoonosis Control, Hokkaido University
  • Kawabata, Ryoko
    Graduate School of Biomedical and Health Sciences, Hiroshima University
  • Watanabe, Yukio
    Center for iPS Cell Research and Application (CiRA), Kyoto University
  • Sakamoto, Ayaka
    Center for iPS Cell Research and Application (CiRA), Kyoto University
  • Yasuhara, Naoko
    Center for iPS Cell Research and Application (CiRA), Kyoto University
  • Suzuki, Tateki
    Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University
  • Nakajima, Yukari
    Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University
  • Ferdous, Zannatul
    Department of Cancer Pathology, Faculty of Medicine, Hokkaido University
  • Shishido, Kenji
    Department of Cancer Pathology, Faculty of Medicine, Hokkaido University
  • Mugita, Yuka
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Takahashi, Otowa
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Ichihara, Kimiko
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Kaku, Yu
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Misawa, Naoko
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Guo, Ziyi
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Hinay, Alfredo
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Kosugi, Yusuke
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo Graduate School of Medicine, The University of Tokyo
  • Fujita, Shigeru
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo Graduate School of Medicine, The University of Tokyo
  • Tolentino, Jarel M.
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
  • Chen, Luo
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo Graduate School of Medicine, The University of Tokyo
  • Pan, Lin
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
  • Suganami, Mai
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Chiba, Mika
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Yoshimura, Ryo
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Yasuda, Kyoko
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Iida, Keiko
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Ohsumi, Naomi
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Strange, Adam P.
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Shibatani, Yuki
    Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
  • Nishiuchi, Tomoko
    Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
  • Tanaka, Shiho
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Putri, Olivia
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Joas, Gustav
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Kim, Yoonjin
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
  • Yamasoba, Daichi
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo School of Medicine, Kobe University
  • Yoshimura, Kazuhisa
    Tokyo Metropolitan Institute of Public Health
  • Sadamasu, Kenji
    Tokyo Metropolitan Institute of Public Health
  • Nagashima, Mami
    Tokyo Metropolitan Institute of Public Health
  • Asakura, Hiroyuki
    Tokyo Metropolitan Institute of Public Health
  • Takaori-Kondo, Akifumi
    Kyoto University
  • Nagata, Kayoko
    Kyoto University
  • Kawai, Yugo
    Kyoto University
  • Ueno, Takamasa
    Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University
  • Motozono, Chihiro
    Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University
  • Toyoda, Mako
    Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University
  • Ikeda, Terumasa
    Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
  • Saito, Akatsuki
    Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki Center for Animal Disease Control, University of Miyazaki
  • Matsuno, Keita
    One Health Research Center, Hokkaido University Division of Risk Analysis and Management, International Institute for Zoonosis Control, Hokkaido University International Collaboration Unit, International Institute for Zoonosis Control, Hokkaido University
  • Ito, Jumpei
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
  • Tanaka, Shinya
    Department of Cancer Pathology, Faculty of Medicine, Hokkaido University Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
  • Sato, Kei
    Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo Graduate School of Medicine, The University of Tokyo International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo Graduate School of Frontier Sciences, The University of Tokyo CREST, Japan Science and Technology Agency International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo Collaboration Unit for Infection, Joint Research Center for Human Retrovirus Infection, Kumamoto University
  • Hashiguchi, Takao
    Laboratory of Medical Virology, Institute for Life and Medical Sciences, Kyoto University Graduate School of Frontier Sciences, The University of Tokyo Kyoto University Immunomonitoring Center, Kyoto University
  • Takayama, Kazuo
    Center for iPS Cell Research and Application (CiRA), Kyoto University AMED-CREST, Japan Agency for Medical Research and Development (AMED)
  • Fukuhara, Takasuke
    Department of Microbiology and Immunology, Faculty of Medicine, Hokkaido University Graduate School of Medicine, Hokkaido University School of Medicine, Hokkaido University Institute for the Advancement of Higher Education, Hokkaido University Institute for Vaccine Research and Development (IVReD), Hokkaido University One Health Research Center, Hokkaido University Kyoto University Immunomonitoring Center, Kyoto University Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University

Description

Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5.

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Details 詳細情報について

  • CRID
    1050019204192481536
  • ISSN
    20411723
  • HANDLE
    2324/7182182
    2433/287044
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB

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