Rhodium-Catalyzed Synthesis of Peptide Polysulfides by Insertion of Sulfur into Unprotected Peptide Disulfides
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- Fukumoto, Kohei
- Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Yazaki, Masana
- Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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- Arisawa, Mieko
- Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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Description
A rhodium-catalyzed insertion of sulfur into unprotected peptide disulfides in aqueous solvents has been developed, which yields mixtures of trisulfides and tetrasulfides. This method can be applied to peptides containing amino acids such as Gly, Phe, Tyr, Ser, Met, Asp, Gln, and Lys and provides polysulfides with various amino acid residues without being affected by functional groups. A reaction can be conducted on a gram scale. Vasopressin can also be converted into its corresponding polysulfides.
Journal
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- Organic Letters
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Organic Letters 24 (44), 8176-8179, 2022-11-01
American Chemical Society (ACS)
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Details 詳細情報について
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- CRID
- 1050019512842661248
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- NII Book ID
- AA11347843
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- ISSN
- 15237052
- 15237060
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- HANDLE
- 2324/7183558
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB