Rhodium-Catalyzed Synthesis of Peptide Polysulfides by Insertion of Sulfur into Unprotected Peptide Disulfides

IR (HANDLE) Open Access
  • Fukumoto, Kohei
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Department of Organic Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University
  • Yazaki, Masana
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
  • Arisawa, Mieko
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University

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Description

A rhodium-catalyzed insertion of sulfur into unprotected peptide disulfides in aqueous solvents has been developed, which yields mixtures of trisulfides and tetrasulfides. This method can be applied to peptides containing amino acids such as Gly, Phe, Tyr, Ser, Met, Asp, Gln, and Lys and provides polysulfides with various amino acid residues without being affected by functional groups. A reaction can be conducted on a gram scale. Vasopressin can also be converted into its corresponding polysulfides.

Journal

  • Organic Letters

    Organic Letters 24 (44), 8176-8179, 2022-11-01

    American Chemical Society (ACS)

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Details 詳細情報について

  • CRID
    1050019512842661248
  • NII Book ID
    AA11347843
  • ISSN
    15237052
    15237060
  • HANDLE
    2324/7183558
  • Text Lang
    en
  • Article Type
    journal article
  • Data Source
    • IRDB

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