環境要因の健康リスク評価と疾病予防への貢献

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  • カンキョウ ヨウイン ノ ケンコウ リスク ヒョウカ ト シッペイ ヨボウ エノ コウケン
  • Risk assessment of environmental factors and contribution to disease prevention

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The research interest of authors has focused on the risk assessment of environmental pollutants such as cadmium and dioxin-related compounds, and epidemiology of human T-cell lymphotropic virus type-I （HTLV-I） infection. The authors （１） showed that low-molecular weight proteinuria and reduced glomerular filtration rate caused by environmental cadmium were strongly associated with shortened survival， （２） clarified serological risk factors for development of adult T-cell leukemia/lymphoma among asymptomatic HTLV-I carriers （plasma levels of soluble interleukin２-receptor＞＝５００U/ml and HTLV-I antibody titer＞＝１，０２４）， （３） conducted the first prospective study of HTLV-I infection and development of malignances other than ATL, and found a significantly reduced risk of gastric cancer among HTLV-I carriers, and （４） by a cooperative study, clarified a new pathogenicity of HTLV-I （association with Sjögren’s syndrome）.

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