Neonatal metabolic alkalosis and mild diuresis resulting from torasemide self-medication by the mother: a case report

機関リポジトリ (HANDLE) オープンアクセス

説明

Background: Torasemide, a loop diuretic, is rarely used for pregnant women because of the risk of reduced placental blood flow resulting from decreased circulating plasma volume. We experienced a case of a newborn with metabolic alkalosis and mild polyuria. The mother was suspected of self-medicating as we detected torasemide in the neonatal serum by LC-MS/MS method. Case presentation: A Japanese pregnant woman in her 20s with mental illness, symptoms of panic and eating disorders, and a history of overdosing on over-the-counter medications, was referred to our hospital for birth control. She presented with vomiting following bulimia nervosa and hypokalemia. Her baby was delivered vaginally at 36 weeks and 4 days of gestation. The baby’s blood gas analysis on day 0 revealed metabolic alkalosis (pH > 7.42, HCO₃⁻ > 28 mmHg). Up to 16 h after birth, mild polyuria and a urine output of 3.3 mL/kg/h were observed without the administration of diuretics. We suspected diuretic intake by the mother before delivery, because she had a history of taking torasemide before being referred to the hospital. As expected, torasemide was detected in the baby’s serum. The serum concentration on the first day after delivery (4.80 ng/mL) gradually decreased to 0.45 ng/mL on day 5, whereas torasemide was not detected in the maternal serum. Neonatal metabolic alkalosis improved by day 3 following birth. Conclusions: This case suggests close counseling and monitoring of pregnant women before childbirth regarding their past and present use of drugs, particularly in those with mental illness.

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詳細情報 詳細情報について

  • CRID
    1050022543170426624
  • ISSN
    20550294
  • HANDLE
    20.500.14094/0100495645
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB

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