＜Poster＞Effect of a free radical scavenger, edaravone, on free radical reactions : Related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model

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  • Effect of a free radical scavenger edaravone on free radical reactions related signal transduction and cerebral vasospasm in the rabbit subarachnoid hemorrhage model

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OBJECTIVE: It is hypothesized that free radical reactions evoked by oxyhemoglobin （oxyHb） cause cerebral vasospasm after aneurysmal subarachnoid hemorrhage （SAH）, even though the detailed mechanisms have not yet been fully established. The aims of this study were thus to investigate, through the use of the doublehemorrhage rabbit model, the possibility that using a potent free radical scavenger, edaravone, will show amelioration of cerebral vasospasm, and to delineate the mechanism of signal transduction that causes cerebral vasospasm. METHODS: In the SAH group, SAH was simulated using the double-hemorrhage rabbit model. In the treatment group, edaravone （0.6 mg/kg） was injected into the central ear vein. Ninety-six hours after SAH, the basilar artery was excised. The degree of cerebral vasospasm was evaluated by measuring the diameter of each basilar artery, and the expression of Rho-kinase in the vascular wall was examined by Western blotting. RESULTS: The diameter of the basilar artery in the edaravone-treated group was 0.71 ± 0.06 mm, which was statistically signifi cantly larger than that in the nontreated SAH group （0.50 ± 0.03 mm; P < 0.01）. The expression of Rho-kinase in the edaravonetreated group was statistically signifi cantly reduced in comparison to that of the nontreated SAH group （P < 0.01）. CONCLUSION: Results from this study indicate that edaravone may potentially serve as an agent in the prevention of cerebral vasospasm in patients after SAH. In addition, it might be suggested that the free radical reaction mediated by oxyHb is concerned with the regulation of the Rho/Rho-kinase pathway.

弘前医学. 61(Suppl.), 2010, p.S197-S203

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  • 弘前医学

    弘前医学 61 (Supplement), S197-S203, 2010-07-08

    弘前大学大学院医学研究科・弘前医学会

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