＜Poster＞Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews

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  • Innate immunity is up regulated by a virulence factor p60 derived from Listeria monocytogenes

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We investigated the eff ect of p60 that is one of virulence factors of Listeria monocytogenes on host immune response in vitro and in vivo. C57BL/6 mice immunized with p60 showed antigen-specifi c T-helper I type immune response. Mouse macrophage RAW264.7 cells produced tumor necrosis factor alpha （TNF-α）, interleukin-12 and interferon beta （IFN-β） in response to stimulation with recombinant p60. Administration of p60 prior to a sublethal infection with L. monocytogenes enhanced innate host resistance in naïve mice. TNF-α and IFN-β production from RAW264.7 cells and bone marrow-derived macrophages were Toll-like receptor 4 （TLR4）-dependent. The enhanced clearance of L. monocytogenes by p60 administration was not shown in C3H/HeJ mice. Our fi ndings demonstrated that p60 enhances host resistance against L. monocytngenes infection through both activation and attenuation of host innate immune response in the TLR4-dependent manner.

弘前医学. 61(Suppl.), 2010, p.S224-S231

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  • 弘前医学

    弘前医学 61 (Supplement), S224-S231, 2010-07-08

    弘前大学大学院医学研究科・弘前医学会

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