Two Cases of Urolithiasis Induced by Topiramate

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Other Title
  • トピラマート（トピナⓇ）服用中に腎尿管結石を生じたてんかん患者の2例
  • トピラマート(トピナ)服用中に腎尿管結石を生じたてんかん患者の2例
  • トピラマート トピナ フクヨウ チュウ ニ ジンニョウカン ケッセキ オ ショウジタ テンカン カンジャ ノ 2レイ

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Abstract

Topiramate is an antiepileptic medicine that has been used adjunctively in the treatment of refractory seizures in Japan since 2007. Topiramate has been shown to inhibit specific carbonic anhydrase activity in the kidney and may induce a distal type of renal tubular acidosis. Case 1 : A 22-year-old male was referred to our hospital after complaining of left flank pain. He developed a seizure disorder and had been using topiramate for 4 months. Drip infusion pyelography showed a left ureteral stone. Case 2 : A 7-year-old boy presented with gross hematuria. He developed West syndrome and had been using topiramate for 6 months. A computed tomographic scan showed a right kidney stone.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 57 (3), 125-128, 2011-03-31

    泌尿器科紀要刊行会

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